In Tiletum, you and your fellow players take on the roles of rich merchants traveling throughout Europe, from the city of Tiletum (modern-day Tielt, Belgium) to Venice, during the days of early Renaissance.

You will travel to various cities to acquire trade contracts for wool and iron and establish trade houses. You must collect the required resources to fulfill contracts, invest in the construction of monumental cathedrals, gain the favor of noble families, and participate in important fairs, where your main business occurs. You will also use the services of notable people who will be welcomed into your houses. You will thus gain prestige that will make you the most famous merchant of the early Renaissance.

Tiletum is a dice management game in which dice have a dual function: gaining resources and performing actions. A certain number of dice will be rolled each round. On your turn, choose a die to gain the number of corresponding resources equal to the value of the die, then perform the associated action. The power of the action is inversely proportional to the value of the die, so the fewer resources you gain, the more powerful the actions you take and vice versa.